Les macroprogestatifs sont des pilules à base de progestérone à forte dose utilisés dans l’insuffisance lutéale, des pathologies endométriales et mammaires bénignes et dans le traitement hormonale substitutif de la ménopause. Ce sont des pilules prises entre 20 et 21 jours avec selon 7 à 8 jours d’arrêt, ou en continu pour empécher la survenue de règles.
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